Chemo for triple negative breast cancer

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March 28, , by NCI Staff. Triple-negative breast cancer cells exhibit a great deal of heterogeneity, which makes it challenging to manage the disease. UPDATE: Updated findings from the IMpassion trial—published November 27, , in The Lancet Oncology —showed that there was no improvement in how long patients who received atezolizumab in combination with nab-paclitaxel lived compared with those who received a placebo and nab-paclitaxel. However, in patients whose tumors tested positive for expression of the PD-L1 protein, the median overall survival of atezolizumab-treated patients was 25 months compared with 18 months for those who received nab-paclitaxel and a placebo.
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Triple negative breast cancer

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Triple negative breast cancer | Cancer Research UK

Because the cancer cells lack these proteins, treatment options for triple-negative breast cancer are limited. Hormone therapy and drugs that target HER2 are not helpful, so chemotherapy is the main systemic treatment option. And although, TNBC tends to respond well to initial chemotherapy, it tends to come back recur more frequently than other breast cancers. If the early-stage TNBC tumor is small enough for surgery then breast-conserving surgery or a mastectomy with a check of the lymph nodes may be done.
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U.S. Food and Drug Administration

Ayca Gucalp, Tiffany A. Patients with TNBC generally experience a more aggressive clinical course with increased risk of disease progression and poorer overall survival. Furthermore, this subtype accounts for a disproportionate number of disease-related mortality in part due to its aggressive natural history and our lack of effective targeted agents beyond conventional cytotoxic chemotherapy. In this paper, we will review the epidemiology, risk factors, prognosis, and the molecular and clinicopathologic features that distinguish TNBC from other subtypes of breast cancer.
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Questions about the survival rate and recurrence rate are very common when someone is diagnosed with triple-negative breast cancer TNBC. While prognosis is, on average, poorer than with hormone receptor or human epidermal growth factor receptor 2 HER2 positive tumors, triple-negative breast cancer is a very heterogeneous diverse disease. On a positive note, and unlike hormone-positive tumors that commonly recur late after five years , late recurrence is less common with triple-negative tumors.

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