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Glutamate receptor delta 2 GluRd2 is selectively expressed in the cerebellum, exclusively in the spines of the Purkinje cells PCs that are in contact with parallel fibers PFs. Although its structure is similar to ionotropic glutamate receptors, it has no channel function and its ligand is unknown. The GluRd2-null mice, such as knockout and hotfoot have profoundly altered cerebellar circuitry, which causes ataxia and impaired motor learning. In addition, GluRd2 participates in the highly territorial competition between the two excitatory inputs to the PC; the climbing fiber CF , which innervates the proximal dendritic compartment, and the PF, which is connected to spiny distal branchlets. Here, we provide in vivo and in vitro evidence that supports this hypothesis.
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We encountered a case of a year-old male who had both unilateral hypermature cataract and central retinal vein occlusion in his left eye. His left eye showed lens subluxation at 2 months after the first examination and central retinal vein occlusion was found after cataract surgery. Then rubeosis iridis developed rapidly in one week and resulted in neovascular glaucoma. His right eye had no abnormal ocular findings.
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